diff --git a/CMakeLists.txt b/CMakeLists.txt
index 994f58668..3785dd223 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -113,7 +113,10 @@ endif()
 # global compiler flags
 if(NOT WIN32)
 # MSYS2 needs -lssp and -fstack-protector for _FORTIFY_SOURCE
+# macOS with ASAN can't handle _FORTIFY_SOURCE != 1
+if(NOT ${USE_ASAN})
 add_compile_definitions(_FORTIFY_SOURCE=2)
+endif()
 add_compile_options(-Wformat -Werror=format-security)
 endif()
 if(MSVC)